Blar i forfatter "Barge, Bente Sirin"

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    • Computer Simulations of Antimicrobial Tripeptides with Proteolytic Stability Towards Chymotrypsin 

      Barge, Bente Sirin (Master thesis; Mastergradsoppgave, 2019-12-05)
      The emerging crisis of antimicrobial resistance calls for the development of new therapeutic drugs. Antimicrobial peptides (AMPs), found in a variety of species as part of the host-defence mechanisms, serves as promising candidates for clinical use. Studies of well-known AMPs like lactoferrin have lead to the preparation of short cationic AMPs (CAPs) with broad spectrum antimicrobial activity against ...

    • Data-driven approaches for identifying hyperparameters in multi-step retrosynthesis 

      Westerlund, Annie M.; Barge, Bente Sirin; Mervin, Lewis; Genheden, Samuel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
      The multi-step retrosynthesis problem can be solved by a search algorithm, such as Monte Carlo tree search (MCTS). The performance of multistep retrosynthesis, as measured by a trade-off in search time and route solvability, therefore depends on the hyperparameters of the search algorithm. In this paper, we demonstrated the effect of three MCTS hyperparameters (number of iterations, tree depth, and ...